Published

Life Sciences

Electrical Sensing of sickled red blood cells subpopulations in microfluidic device

Published on - MicroTAS

Authors: Tieying Xu, Maria A Lizarralde-Iragorri, Jean Roman, Emile Martincic, Valentine Brousse, Olivier Français, Wassim El Nemer, Bruno Le Pioufle

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This paper discusses the electrical sensing of red blood cell (RBC) rigidity due to Hemoglobin S (HbS) polymerization in sickle cell disease. For this purpose sickle RBCs subpopulations, differentiated by cell density, were flown through a microfluidic device equipped with integrated microelectrodes. Differences in transit time and electrical blockade were observed and analyzed.